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January 17, 2025: Congratulations! A paper entitled "The widely used Ucp1-Cre transgene elicits complex developmental and metabolic phenotypes" has been published in Nature Communications in collaboration with Sanchez Gumaches lab.
October 10, 2024: Congratulations! A paper entitled "Systematic benchmark of single-cell hashtag demultiplexing approaches reveals robust performance of a clustering-based method" has been published in Briefings in Functional Genomics.
September 20, 2024: Congratulations! A protocol paper entitled "Protocol for establishing inducible CRISPRd system for blocking transcription factor-binding sites in human pluripotent stem cells" has been published in STAR Protocols in collaboration with Iwafuchi lab.
June 25, 2024: Congratulations! A paper entitled "Myeloid-derived miR-6236 potentiates adipocyte insulin signaling and prevents hyperglycemia during obesity" has been published in Nature Communications in collaboration with Hill lab.
June 17, 2024: Congratulations! A paper entitled "Short-term cold exposure induces persistent epigenomic memory in brown fat" has been published in Cell Metabolism in collaboration with Lazar lab.
January 30, 2024: Congratulations! A paper entitled "Microbiota-derived butyrate restricts tuft cell differentiation via histone deacetylase 3 to modulate intestinal type 2 immunity" has been published in Immunity in collaboration with Alenghat lab.
January 10, 2024: Great news for the new year! Four years of collaboration with Dr. Iwafuchi lab. finally has been published in Molecular Cell. The title is "Pioneer and PRDM transcription factors coordinate bivalent epigenetic states to safeguard cell fate". This is our lab's second corresponding author paper! Congratulations!
December 19, 2023: Congratulations! A paper entitled "Single-cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia" has been published in Cell Reports Medicine in collaboration with Sanchez-Gurmaches lab. It is on the cover!
October 20, 2023: Congratulations! A preprint is now online in bioRxiv with the title "The widely used Ucp1-CreEvdr transgene elicits complex developmental and metabolic phenotypes" in collaboration with Sanchez-Gurmaches lab.
September 7, 2023: Congratulations! A paper entitled "Sinus venosus adaptation models prolonged cardiovascular disease and reveals insights into evolutionary transitions of the vertebrate heart" was published in Nature Communications in collaboration with Waxman lab.
August 14, 2023: Congratulations! A preprint is now online in bioRxiv with the title "Hedgehog signaling is required for the maintenance of mesenchymal nephron progenitors" in collaboration with Park lab.
July 7, 2023: Congratulations! A paper entitled "Prediction of cooperative homeodomain DNA binding sites from high-throughput-SELEX data" was published in Nucleic Acids Research in collaboration with Gebelein lab and Campbell lab at CCHMC!
February 13, 2023: Congratulations! A Preprint is now online in bioRxiv with the title "Pioneer transcription factors coordinate active and repressive gene expression states to regulate cell fate" in collaboration with Sanchez-Gurmaches lab.
December 29, 2022: Congratulations! A Preprint is now online in bioRxiv with the title "Single cell transcriptomics identifies adipose tissue CD271+ progenitors for enhanced angiogenesis in limb ischemia". Our collaboration with Iwafuchi lab for the last 4 years is finally out!
December 14, 2022: Congratulations! ADA junior faculty award got funded in collaboration with Wang lab at Florida State University. Dr. Lim is participating as a co-I.
November 26, 2022: Congratulations! A book chapter entitled "Profiling Accessible Chromatin and Nucleosomes in the Mammalian Genome" was published in collaboration with Iwafuchi lab!
August 30, 2022: Our major collaborator, Iwafuchi lab received R01 from NIH/NIGHS. Congratulations! We'll study unconventional functions of pioneering factors!
July 1, 2022: Our recently published paper in JCI Insight was featured in JCI This Month as Editor's Pick!
June 8, 2022: Our first corresponding author paper in the lab is officially published in JCI Insight and featured on the cover!
May 16, 2022: Congratulations! A paper entitled "Global-run on sequencing identifies Gm11967 as an Akt-dependent long noncoding RNA involved in insulin sensitivity" has been published in iScience in collaboration with Titchenell Lab in UPENN.
Apr 26, 2022: First corresponding author paper in the lab! Congratulations! A paper entitled "Single-cell RNA sequencing of human esophageal epithelium in homeostasis and allergic inflammation" has been published online in JCI Insight in collaboration with Rothenberg Lab in CCHMC.
Mar 10, 2022: Congratulations! A paper entitled "Formation of the mouse internal capsule and cerebral peduncle: A pioneering role for striatonigral axons as revealed in Isl1 conditional mutants" has been published online in The Journal of Neuroscience in collaboration with Campbell lab in CCHMC.
Jan 17, 2022: Congratulations! A paper entitled "Neurobehavioral abnormalities following prenatal psychosocial stress are differentially modulated by maternal environment" has been published online in Translational Psychiatry in collaboration with Muglia lab in CCHMC and Burroughs Wellcome Fund.
Previous News
Previous News
Dec 14, 2021: Congratulations! A paper entitled "Defective brown adipose tissue thermogenesis and impaired glucose metabolism in mice lacking Letmd1" has been accepted for publication in Cell Reports in collaboration with Yoon Lab, UC Davis.
Oct 12, 2021: Congratulations! A paper entitled "JMJD8 is a Novel Molecular Nexus Between Adipocyte-Intrinsic Inflammation and Insulin Resistance" has been accepted for publication in Diabetes in collaboration with Kang lab, UC Berkeley.
Aug 9, 2021: Congratulations! A paper entitled "Identification of intima-to-media signals for flow-induced vascular remodeling using correlative gene expression analysis" has been published in Scientific Reports in collaboration with Kolega lab, University of Buffalo.
Jun 15, 2021: Dr. Mohammed Sayed joined the lab as a postdoctoral research fellow. Welcome aboard!
Jun 3, 2021: Congratulations! A paper entitled "The Scleraxis Transcription Factor Directly Regulates Multiple Distinct Molecular and Cellular Processes During Early Tendon Cell Differentiation" has been published in Frontiers in Cell and Developmental Biology in collaboration with Jiang lab in CCHMC.
Jun 1, 2021: How exciting! Lim lab and Sanchez Gurmaches lab jointly secured a Center for Pediatric Genomics (CpG) pilot award to study Akt-ChREBP regulatory axis for brown fat function by genomewide analysis of enhancer RNA transcription.
Apr 13, 2021: Congratulations! A paper entitled "A necessary role of DNMT3A in endurance exercise by suppressing ALDH1L1‐mediated oxidative stress" has been published in EMBO Journal after a year-long collaboration with Dr. Kang's laboratory at UC Berkeley
Jan 1, 2021: Congratulations! Paper entitled "Conserved Gsx2/Ind homeodomain monomer versus homodimer DNA binding defines regulatory outcomes in flies and mice" have been published in Genes & Development. Especially exciting first publication from internal collaboration with Gebelein lab and Campbell lab at CCHMC!
Sep 16, 2020: Lim gave a talk at the Regulatory Genomics Forum at CCHMC about capped small RNA-seq (csRNA-seq) platform and pilot data
Aug 27, 2020: Congratulations! A paper entitled "TET1 is a beige adipocyte-selective epigenetic suppressor of thermogenesis" has been published in Nature Communications after a year-long collaboration with Dr. Kang's laboratory at UC Berkeley
Aug 27, 2020: Juechen Yang (Jason) joined the lab as a rotation student of BMI graduate program, CCHMC
Aug 7, 2020: Congratulations! A paper entitled "Pan-Cancer Analysis of Alternative Lengthening of Telomere Activity" has been published in Cancers in collaboration with the Samsung Genome Institute, Samsung Medical Center, Korea
Aug 4, 2020: Lim officially joined the graduate program in Molecular & Developmental Biology (MDB), CCHMC
Aug 3, 2020: Our first pilot data of capped small RNA-seq (csRNA-seq) has been generated in collaboration with Dr. Hwa lab and Dr. Sanchez Gurmaches lab at CCHMC. First of more to come to study enhancer RNAs and regulatory genomics
Jul 6, 2020: Christopher Ahn, MS, joined the lab as a bioinformatics analyst. Welcome!
Jan 10, 2020: Congratulations! Lim lab got awarded CCHMC Trustee Award to develop a comprehensive computational platform to analyze CUT&RUN data and delineate the underlying heterogeneous chromatin landscape!
Aug 27, 2019: Lim gave a talk at the 15th International Conference on Bioinformatics (BIOINFO 2019), Korea
Aug 12, 2019: Lim gave a talk at the International Symposium on Genomic Medicine 2019 at the Samsung Genome Institute, Korea
Jul 2, 2019: Lim gave a faculty lab research talks at UC Systems Biology Graduate Program
May 9, 2019: Lim gave a talk at the Developmental Biology retreat, CCHMC
May 8, 2019: Lim gave a talk at the A/I club of the Division of Allergy and Immunology, CCHMC
Feb 18, 2019: Lim gave a talk at Experimental Hematology Seminar Series, CCHMC
Jan 7, 2019: Lim Lab opened @ Division of Biomedical Informatics, CCHMC; Department of Pediatrics, University of Cincinnati College of Medicine
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